Gabapentin is the generic name of a prescription drug used to treat epilepsy. Gabapentin works by decreasing abnormal excitement in the brain. It also may change the way the body senses pain. Gabapentin is in a class of medications called anticonvulsants.
The U.S. Food and Drug Administration (FDA) approved gabapentin in 1993 under the brand name Neurontin for the drug manufacturer Pfizer. The medication comes in capsule form, as a regular or extended-release tablet, and as a liquid.
Gabapentin interacts with voltage-sensitive calcium channels in cortical neurons. Gabapentin increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters.
One of the mechanisms implicated in this effect of gabapentin is the reduction of the axon excitability measured as an amplitude change of the presynaptic fibre volley (FV) in the CA1 area of the hippocampus.
This is mediated through its binding to presynaptic NMDA receptors. Other studies have shown that the antihyperalgesic and antiallodynic effects of gabapentin are mediated by the descending noradrenergic system, resulting in the activation of spinal alpha-2 adrenergic receptors. Gabapentin has also been shown to bind and activate the adenosine A1 receptor.
Gabapentin may help to control your condition but will not cure it. Continue to take gabapentin even if you feel well. Do not stop taking gabapentin without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood.
If you suddenly stop taking gabapentin tablets, capsules, or oral solution, you may experience withdrawal symptoms such as anxiety, difficulty falling asleep or staying asleep, nausea, pain, and sweating. If you are taking gabapentin to treat seizures and you suddenly stop taking the medication, you may experience seizures more often.
Your doctor may decrease your dose gradually over at least a week.
A lot of patients order fioricet or buy fioricet in order to stop their tension headache or general headaches.
normally 53% headaches are tension headaches and 39% are migraines. Other kinds of headaches only occupy eight percent.
The best way to relieve your headaches are preventing your headache before it begins.
You have to know your headache triggers. Normally it is because of stress. But there are a lot of headache triggers there including weather,strong smell, Hair Accessories, sex and Exercise, Poor Posture, Cheese, Red Wine, food, Cold Cuts, Skipping Meals, Smoking, Caffeine,
If you can identify your most common triggers, you may be able to cut off headaches before they start. The best way to accomplish this is through a headache diary.
Keep a daily log of foods you eat, stressful events, weather changes, and physical activity. Whenever you have a headache, record the time it starts and stops.
A headache diary includes:
Day and time the pain began;
What you ate and drank over the past 24 hours;
How much you slept;
and physical activity;
How long the headache lasted and what made it stop
Review your diary with your doctor to identify triggers or a pattern to your headaches. This can help you and your doctor create a treatment plan. Knowing your triggers can help you avoid them.
Emotional stress is one of the most common triggers of migraines and tension headaches ( stress headaches). Migraine sufferers are generally found to be more emotional and highly affected by stressful events. During stressful events certain chemicals in the brain are released to combat the situation (known as the ‘fight or flight’ response). The release of these chemicals can provoke blood vessel changes that can cause migraine headaches.
Stress is also an important factor in tension headaches. Tension headaches can either be episodic or chronic. Episodic tension headache is usually triggered by an isolated stressful situation or a build-up of stress; it can usually be treated by over-the-counter painkillers. Daily stress such as from a high-pressure job can lead to chronic tension headaches. Treatment for chronic tension headaches usually involves stress management, counselling, and possibly the use of antidepressant or anxiety reducing medication.
Stress management involves learning to be able to control stress and relax. Everyone has periods of stress. Stress has benefits in that it can result in us pushing ourselves and getting things done. This can precipitate a headache. Simply taking some deep breaths and maybe tensing then relaxing your muscles can relieve occasional mild stress. Regular stress may require learning to say “no”, not taking too much on. Becoming fit, eating regularly, and proper sleep can help combat stress. Learn better organizing skills, not setting standards that are too high and deal with problems as they arise, can all help. As can, adopting stress management techniques such as meditation, biofeedback, relaxation therapy and yoga.
Lifestyle changes that may help to prevent your headache, include:
Use a different pillow or change sleeping positions.
Practice good posture when reading, working, or doing other activities.
Exercise and stretch your back, neck, and shoulders often when typing, working on computers, or doing other close work.
Get more vigorous exercise. This is exercise that gets your heart beating fast. (Check with your health care provider about what kind of exercise is best for you.)
Have your eyes checked. If you have glasses, use them.
Learn and practice stress management. Some people find relaxation exercises or meditation helpful.
Eat Regularly, Eating balanced meals throughout the day will help keep your blood sugar on an even keel
Physical Therapy, Physical therapy combines exercise and education to reduce pain and improve range of motion
Some people can prevent migraines by avoiding triggers. Others have prevented migraines successfully through relaxation techniques, acupuncture, or exercise. However, these therapies alone don’t work for everyone.
Some people also need treatment with medication to reduce the number of migraines they have. The drugs used to prevent migraines are different from drugs that to treat migraines once a migraine starts.
Drugs that prevent migraines, such as gabapentin, must be taken on an ongoing basis to work properly.
Over-the counter pain relievers such as acetaminophen, aspirin, ibuprofen, and naproxen are effective against many types of headaches. But avoid taking these drugs continuously, as this can result in medication overuse headaches or rebound headaches — headache pain that returns as soon as the pills have worn off.
For frequent or severe headaches, talk to your doctor about prescription medications that help prevent them.
Your doctor may recommend that you take a prescription medicine every day to prevent headaches. You may want to take this medicine if:
Over-the-counter medicines don’t work to stop your headaches.
You’re taking drugs to stop headaches more than 3 times a week.
You get a headache more than 15 days a month.
Medicines used to prevent tension headaches include:
Antidepressants, such as amitriptyline.
Seizure medicines, such as topiramate and Gabapentin
Medicines that relax muscles, such as tizanidine.
Antianxiety medicines, such as buspirone.
To compare gabapentin with placebo for use as a prophylactic agent in patients with migraine (with or without aura).
NIH has list an article about
Efficacy of gabapentin in migraine prophylaxis
STUDY DESIGN AND TREATMENT:
After screening, a 4-week, single-blind, placebo baseline period was followed by a 12-week, double-blind, treatment period. The 12-week treatment period consisted of a 4-week titration phase and an 8-week stable-dosing phase.
During the 4-week titration phase, patients were started on one 300-mg capsule of gabapentin or matching placebo. Patients were titrated weekly from 900 mg/day (end of week 1) to 2400 mg/day (end of week 4) and had to be receiving a stable dose of study medication by the end of the titration period.
Study medication was to be given on a three-times-a-day dosing regimen.
Their conclusion: Gabapentin is an effective prophylactic agent for patients with migraine. In addition, gabapentin appears generally well tolerated with mild to moderate somnolence and dizziness.
For more information, please check Efficacy of gabapentin in migraine prophylaxis. ( http://ezfioricet.com/2014/09/how-to-prevent-headache/ )
By patient reviews, 80% patients think Gabapentin is good for Migraine Prevent: